IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts.

doi:10.1182/blood-2013-06-506865

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Article

IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts.

Blood - 5 Dec 2013

Berglund Lucinda J, Avery Danielle T, Ma Cindy S, Moens Leen, Deenick Elissa K, Bustamante Jacinta, Boisson-Dupuis Stephanie, Wong Melanie, Adelstein Stephen, Arkwright Peter D, Bacchetta Rosa, Bezrodnik Liliana, Dadi Harjit, Roifman Chaim M, Fulcher David A, Ziegler John B, Smart Joanne M, Kobayashi Masao, Picard Capucine, Durandy Anne, Cook Matthew C, Casanova Jean-Laurent, Uzel Gulbu, Tangye Stuart G

Abstract excerpt

B-cell responses are guided by the integration of signals through the B-cell receptor (BCR), CD40, and cytokine receptors. The common γ chain (γc)-binding cytokine interleukin (IL)-21 drives humoral immune responses via STAT3-dependent induction of transcription factors required for plasma cell generation. We investigated additional mechanisms by which IL-21/STAT3 signaling modulates human B-cell responses by...

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PMID: 24159173
DOI: 10.1182/blood-2013-06-506865
PMCID: PMC3854113

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STAT3
BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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