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Article

IL-21 Rescues the Defect of IL-10-Producing Regulatory B Cells and Improves Allergic Asthma in DOCK8 Deficient Mice.

Frontiers in immunology - 1 Jan 2021

Jiang Jinqiu, Qin Tao, Zhang Liang, Liu Qiao, Wu Jiabin, Dai Rongxin, Zhou Lina, Zhao Qin, Luo Xiaoyan, Wang Hua, Zhao Xiaodong

Abstract excerpt

Mutations in human DOCK8 cause a combined immunodeficiency syndrome characterized by allergic diseases such as asthma and food allergy. However, the underlying mechanism is unclear. Regulatory B (Breg) cells that produce IL-10 exert potent immunosuppressive functions in patients with allergic and autoimmune disorders. DOCK8-deficient B cells show diminished responses to TLR9 signaling, suggesting a possible...

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Identifiers

PMID: 34867940
DOI: 10.3389/fimmu.2021.695596
PMCID: PMC8636116

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