Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells.

doi:10.1084/jem.20130323

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Article

Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells.

The Journal of experimental medicine - 18 Nov 2013

Deenick Elissa K, Avery Danielle T, Chan Anna, Berglund Lucinda J, Ives Megan L, Moens Leen, Stoddard Jennifer L, Bustamante Jacinta, Boisson-Dupuis Stephanie, Tsumura Miyuki, Kobayashi Masao, Arkwright Peter D, Averbuch Diana, Engelhard Dan, Roesler Joachim, Peake Jane, Wong Melanie, Adelstein Stephen, Choo Sharon, Smart Joanne M, French Martyn A, Fulcher David A, Cook Matthew C, Picard Capucine, Durandy Anne, Klein Christoph, Holland Steven M, Uzel Gulbu, Casanova Jean-Laurent, Ma Cindy S, Tangye Stuart G

Abstract excerpt

Long-lived antibody memory is mediated by the combined effects of long-lived plasma cells (PCs) and memory B cells generated in response to T cell-dependent antigens (Ags). IL-10 and IL-21 can activate multiple signaling pathways, including STAT1, STAT3, and STAT5; ERK; PI3K/Akt, and potently promote human B cell differentiation. We previously showed that loss-of-function mutations in STAT3, but not STAT1,...

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PMID: 24218138
DOI: 10.1084/jem.20130323
PMCID: PMC3832925

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STAT3
STAT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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