Article

The γc family of cytokines: fine-tuning signals from IL-2 and IL-21 in the regulation of the immune response

2017-10-23

Abstract excerpt

Interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21 form a family of cytokines based on the sharing of a receptor component, the common cytokine receptor γ chain, γ c , which is encoded by the gene mutated in humans with X-linked severe combined immunodeficiency (XSCID). Together, these cytokines play critical roles in lymphoid development, differentiation, growth, and survival as well as mediating effector fun...

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Literature Corpus work: bab798d1-7c50-54f9-a66f-ab5f708357af
DOI: 10.12688/f1000research.12202.1

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