Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Blimp-1 is essential for allergen-induced asthma and Th2 cell development in the lung

4 Apr 2020

Abstract excerpt

A Th2 immune response is central to allergic airway inflammation, which afflicts millions worldwide. However, the mechanisms that augment GATA3 expression in an antigen-primed developing Th2 cell are not well understood. Here, we describe an unexpected role for Blimp-1, a transcriptional repressor that constrains autoimmunity, as an upstream promoter of GATA3 expression that is critical for Th2 cell development...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma and respiratory diseases
Share to IL-33, ST2, and ILC Pathways
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32399548
DOI: 10.1084/jem.20190742

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Blimp-1 is essential for allergen-induced asthma and Th2 cell development in the lungPMID 32399548Read ↗

Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthmaSemantic proximity Read ↗

GATA3 Regulates the Development and Functions of Innate Lymphoid Cell Subsets at Multiple StagesSemantic proximity Read ↗

Blimp-1 Contributes to the Development and Function of Regulatory B CellsSemantic proximity Read ↗

IL-2- and IL-4-dependent signaling play separate and sequential roles in the differentiation of GATA3-hi TH2 cells in vivoSemantic proximity Read ↗

RNA-binding protein RBM3 negatively regulates innate lymphoid cells (ILCs) and lung inflammationSemantic proximity Read ↗

Immunological function of Blimp-1 in dendritic cells and relevance to autoimmune diseases.Semantic proximity Read ↗

Transcription factor-driven regulation of ILC1 and ILC3Semantic proximity Read ↗

A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammationSemantic proximity Read ↗

Guidance of super-enhancers in regulation of IL-9 induction and airway inflammationSemantic proximity Read ↗

Transcriptional regulation of Th2 cell differentiationSemantic proximity Read ↗

Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 CellsSemantic proximity Read ↗

IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.