Article

A CD40-Targeted IL-21 Fusokine Enables Rapid Generation of Human IL-10⁺Granzyme B⁺ Regulatory B Cells

2026-01-13

Abstract excerpt

Regulatory B cells (Bregs) have emerged as important modulators of immune homeostasis, complementing the classical roles of B cells in antibody production, antigen presentation, and provision of costimulatory signals and cytokines. Beyond promoting immunity, B cells can actively suppress inflammatory responses through specialized regulatory programs that limit effector T cell expansion and restrain pathogenic myel...

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Literature Corpus work: 3c7e3100-894f-5a0f-a949-81c6863ca7e5
DOI: 10.64898/2026.01.12.699061

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