Article
Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function.
The Journal of allergy and clinical immunology - 1 Aug 2013
Ives Megan L, Ma Cindy S, Palendira Umaimainthan, Chan Anna, Bustamante Jacinta, Boisson-Dupuis Stephanie, Arkwright Peter D, Engelhard Dan, Averbuch Diana, Magdorf Klaus, Roesler Joachim, Peake Jane, Wong Melanie, Adelstein Stephen, Choo Sharon, Smart Joanne M, French Martyn A, Fulcher David A, Cook Matthew C, Picard Capucine, Durandy Anne, Tsumura Miyuki, Kobayashi Masao, Uzel Gulbu, Casanova Jean-Laurent, Tangye Stuart G, Deenick Elissa K
Abstract excerpt
BACKGROUND: The capacity of CD8(+) T cells to control infections and mediate antitumor immunity requires the development and survival of effector and memory cells. IL-21 has emerged as a potent inducer of CD8(+) T-cell effector function and memory development in mouse models of infectious disease. However, the role of IL-21 and associated signaling pathways in protective CD8(+) T-cell immunity in human subjects...
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