Article
Increased insulin action in SKIP heterozygous knockout mice.
Molecular and cellular biology - 1 Sept 2008
Ijuin Takeshi, Yu Y Eugene, Mizutani Kiyohito, Pao Annie, Tateya Sanshiro, Tamori Yoshikazu, Bradley Allan, Takenawa Tadaomi
Abstract excerpt
Insulin controls glucose homeostasis and lipid metabolism, and insulin impairment plays a critical role in the pathogenesis of diabetes mellitus. Human skeletal muscle and kidney enriched inositol polyphosphate phosphatase (SKIP) is a member of the phosphatidylinositol 3,4,5-trisphosphate phosphatase family (T. Ijuin et al. J. Biol. Chem. 275:10870-10875, 2000; T. Ijuin and T. Takenawa, Mol. Cell. Biol....
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