Article
Transgenic mice deficient in the LAR protein-tyrosine phosphatase exhibit profound defects in glucose homeostasis.
Diabetes - 1 Mar 1998
Ren J M, Li P M, Zhang W R, Sweet L J, Cline G, Shulman G I, Livingston J N, Goldstein B J
Abstract excerpt
Protein-tyrosine phosphatases (PTPases) play an integral role in the regulation of cellular insulin action. LAR, a transmembrane PTPase expressed in insulin-sensitive tissues, acts as a negative regulator of insulin signaling in intact cell models. The physiological role of LAR was studied in mice in which LAR expression was eradicated by insertional mutagenesis. In the fasting state, adult male homozygous LAR...
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