Article
Inositol 1,4,5-trisphosphate receptor 1 mutation perturbs glucose homeostasis and enhances susceptibility to diet-induced diabetes.
The Journal of endocrinology - 1 Aug 2011
Ye Risheng, Ni Min, Wang Miao, Luo Shengzhan, Zhu Genyuan, Chow Robert H, Lee Amy S
Abstract excerpt
The inositol 1,4,5-trisphosphate receptors (IP3Rs) as ligand-gated Ca(2)(+) channels are key modulators of cellular processes. Despite advances in understanding their critical role in regulating neuronal function and cell death, how this family of proteins impact cell metabolism is just emerging....
Topics
- Animals
- Diabetes Mellitus, Type 2
- Dietary Fats
- Disease Susceptibility
- Glucose
- Glucose Intolerance
- Homeostasis
- Inositol 1,4,5-Trisphosphate Receptors
- Insulin
- Insulin-Secreting Cells
- Male