Article
Haploinsufficiency of the Insulin Receptor in the Presence of a Splice-Site Mutation in Ppp2r2a Results in a Novel Digenic Mouse Model of Type 2 Diabetes.
Diabetes - 1 May 2016
Goldsworthy Michelle, Bai Ying, Li Chi-Ming, Ge Huanying, Lamas Edwin, Hilton Helen, Esapa Christopher T, Baker Dan, Baron Will, Juan Todd, Véniant Murielle M, Lloyd David J, Cox Roger D
Abstract excerpt
Insulin resistance in mice typically does not manifest as diabetes due to multiple compensatory mechanisms. Here, we present a novel digenic model of type 2 diabetes in mice heterozygous for a null allele of the insulin receptor and an N-ethyl-N-nitrosourea-induced alternative splice mutation in the regulatory protein phosphatase 2A (PP2A) subunit PPP2R2A. Inheritance of either allele independently results in...
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