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Article

Altered glucose homeostasis in mice lacking the receptor protein tyrosine phosphatase sigma.

Canadian journal of physiology and pharmacology - 1 Jul 2006

Chagnon Mélanie J, Elchebly Mounib, Uetani Noriko, Dombrowski Luce, Cheng Alan, Mooney Robert A, Marette André, Tremblay Michel L

Abstract excerpt

Several protein tyrosine phosphatases (PTPs) expressed in insulin sensitive-tissues are proposed to attenuate insulin action and could act as key regulators of the insulin receptor (IR) signaling pathway. Among these PTPs, RPTPsigma is expressed in relatively high levels in insulin-target tissues. We show that RPTPsigma-/- knockout mice have reduced plasma glucose and insulin concentrations in the fasted state...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16998539
DOI: 10.1139/y06-020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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