Article

Personalized phosphoproteomics of skeletal muscle insulin resistance and exercise links MINDY1 to insulin action

2024-03-13

Abstract excerpt

<h4>Summary</h4> Type 2 diabetes is preceded by a defective insulin response, yet our knowledge of the precise mechanisms is incomplete. Here, we investigate how insulin resistance alters signalling responses in skeletal muscle and how this is modified by exercise. We measured parallel phenotypes and phosphoproteomes of insulin resistant and insulin sensitive individuals as they responded to exercise and insulin (...

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Literature Corpus work: 4b70f2ba-5c53-56bd-a4be-c09aded02aa8
DOI: 10.1101/2024.03.11.24304084

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