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Article

Expanded molecular diversity generation during directed evolution by trinucleotide exchange (TriNEx).

Nucleic acids research - 1 Aug 2008

Baldwin Amy J, Busse Kathy, Simm Alan M, Jones D Dafydd

Abstract excerpt

Trinucleotide exchange (TriNEx) is a method for generating novel molecular diversity during directed evolution by random substitution of one contiguous trinucleotide sequence for another. Single trinucleotide sequences were deleted at random positions in a target gene using the engineered transposon MuDel that were subsequently replaced with a randomized trinucleotide sequence donated by the DNA cassette termed...

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Identifiers

PMID: 18559360
DOI: 10.1093/nar/gkn358
PMCID: PMC2490759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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