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Article

Experimental Prediction of the Natural Evolution of Antibiotic Resistance

1 Apr 2003

Abstract excerpt

The TEM family of beta-lactamases has evolved to confer resistance to most of the beta-lactam antibiotics, but not to cefepime. To determine whether the TEM beta-lactamases have the potential to evolve cefepime resistance, we evolved the ancestral TEM allele, TEM-1, in vitro and selected for cefepime resistance. After four rounds of mutagenesis and selection for increased cefepime resistance each of eight...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12702671
DOI: 10.1093/genetics/163.4.1237

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