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Article

Intense neutral drifts yield robust and evolvable consensus proteins.

Journal of molecular biology - 20 Jun 2008

Bershtein Shimon, Goldin Korina, Tawfik Dan S

Abstract excerpt

What changes occur when a natural protein that had been under low mutation rates is subjected to a neutral drift at high mutational loads, thus generating genetically diverse (polymorphic) gene ensembles that all maintain the protein's original function and structure? To address this question we subjected large populations of TEM-1 beta-lactamase to a prolonged neutral drift, applying high mutation rates and...

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Share to beta-Lactamases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18495157
DOI: 10.1016/j.jmb.2008.04.024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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