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Article

Coupling continuous directed evolution with base editors identifies combinatorial antibiotic resistance.

Biotechnology letters - 20 Sept 2026

Wang Hong, Wang Jiamei, Zhang Di, Shang Guangdong

Abstract excerpt

Antimicrobial resistance (AMR), mainly caused by the mutation of antibiotic resistance genes, poses a great threat to human health. Clinically, TEM-1 β-lactamase encoding blaTEM-1 gene is the most frequently occurred antibiotic resistance gene. Identification, characterization, and monitor of high antibiotic resistance blaTEM-1 mutants are crucial to AMR research and would provide the guidance for the development...

Read the complete abstract on PubMed

Topics

Directed Molecular Evolution
beta-Lactamases
Escherichia coli
Microbial Sensitivity Tests
Anti-Bacterial Agents
Gene Editing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Cefotaxime

Drug Resistance, Bacterial

Chromosomes, Artificial, Bacterial

Source

Identifiers

PMID: 42763377
DOI: 10.1007/s10529-026-03791-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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