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Article

Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau.

Science (New York, N.Y.) - 21 Apr 2000

Lowrey P L, Shimomura K, Antoch M P, Yamazaki S, Zemenides P D, Ralph M R, Menaker M, Takahashi J S

Abstract excerpt

The tau mutation is a semidominant autosomal allele that dramatically shortens period length of circadian rhythms in Syrian hamsters. We report the molecular identification of the tau locus using genetically directed representational difference analysis to define a region of conserved synteny in hamsters with both the mouse and human genomes. The tau locus is encoded by casein kinase I epsilon (CKIepsilon), a...

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Identifiers

PMID: 10775102
DOI: 10.1126/science.288.5465.483
PMCID: PMC3869379

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Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau.PMID 10775102Read ↗

The biology of the circadian Ck1epsilon tau mutation in mice and Syrian hamsters: a tale of two species.Semantic proximity Read ↗

Casein kinase I: another cog in the circadian clockworks.Semantic proximity Read ↗

Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins.Semantic proximity Read ↗

Casein kinase I epsilon gene transfer into the suprachiasmatic nucleus via electroporation lengthens circadian periods of tau mutant hamsters.Semantic proximity Read ↗

The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon.Semantic proximity Read ↗

An opposite role for tau in circadian rhythms revealed by mathematical modeling.Semantic proximity Read ↗

Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome.Semantic proximity Read ↗

Drosophila and vertebrate casein kinase Idelta exhibits evolutionary conservation of circadian function.Semantic proximity Read ↗

Casein kinase I epsilon does not rescue double-time function in Drosophila despite evolutionarily conserved roles in the circadian clock.Semantic proximity Read ↗

Drosophila doubletime mutations which either shorten or lengthen the period of circadian rhythms decrease the protein kinase activity of casein kinase I.Semantic proximity Read ↗

The Tau mutation of casein kinase 1ε sets the period of the mammalian pacemaker via regulation of Period1 or Period2 clock proteins.Semantic proximity Read ↗

Modeling of a human circadian mutation yields insights into clock regulation by PER2.Semantic proximity Read ↗

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