Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau.

doi:10.1126/science.288.5465.483

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Article

Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau.

Science (New York, N.Y.) - 21 Apr 2000

Lowrey P L, Shimomura K, Antoch M P, Yamazaki S, Zemenides P D, Ralph M R, Menaker M, Takahashi J S

Abstract excerpt

The tau mutation is a semidominant autosomal allele that dramatically shortens period length of circadian rhythms in Syrian hamsters. We report the molecular identification of the tau locus using genetically directed representational difference analysis to define a region of conserved synteny in...

Topics

Alleles
Amino Acid Sequence
Amino Acid Substitution
Animals
Casein Kinases
Cell Cycle Proteins
Chromosome Mapping
Circadian Rhythm
Cloning, Molecular
Cricetinae
Female
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Mesocricetus

Mice

Microsatellite Repeats

Molecular Sequence Data

Source

Open in PubMed Open full text

Identifiers

PMID: 10775102
DOI: 10.1126/science.288.5465.483
PMCID: PMC3869379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-10775102-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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