Article
Modeling of a human circadian mutation yields insights into clock regulation by PER2.
Cell - 12 Jan 2007
Xu Y, Toh K L, Jones C R, Shin J-Y, Fu Y-H, Ptácek L J
Abstract excerpt
Circadian rhythms are endogenous oscillations of physiological and behavioral phenomena with period length of approximately 24 hr. A mutation in human Period 2 (hPER2), a gene crucial for resetting the central clock in response to light, is associated with familial advanced sleep phase syndrome (...
Topics
- Amino Acid Sequence
- Animals
- Biological Clocks
- Casein Kinase I
- Cell Nucleus
- Circadian Rhythm
- Gene Expression Regulation
- Glutamic Acid
- Humans
- Mice
- Mice, Transgenic
- Models, Biological
- Molecular Sequence Data
- Mutant Proteins
- Mutation
- Nuclear Proteins
- Peptides
- Period Circadian Proteins