Article
Casein kinase-1-epsilon (CK1epsilon) and circadian photic responses in hamsters.
Chronobiology international - 1 Jan 2009
Agostino Patricia V, Harrington Mary E, Ralph Martin R, Golombek Diego A
Abstract excerpt
Circadian rhythms rely on the interaction of highly conserved transcription-translation loops. Casein kinase I epsilon (CK1epsilon) post-transcriptionally regulates circadian rhythms by phosphorylating clock genes, and the tau mutation, an arginine to cysteine substitution at residue 128, results in a short circadian period, abnormal entrainment to light cycles, and potentiated resetting responses to light. Each...
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