Article

A systemic clock brake: Period1 stabilizes the circadian network under environmental stress

2025-06-15

Abstract excerpt

Precise alignment between internal circadian clocks and environmental light cycles is essential for physiological homeostasis and survival. However, the molecular mechanisms that preserve this synchrony across central and peripheral tissues remain poorly defined. Here, we uncover an unexpected role for the core clock gene Period1 (Per1) as a systemic modulator of circadian stability, regulating light-induced re-e...

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Identifiers and source

Literature Corpus work: 2f839619-dc72-51cc-8092-4d499b0227db
DOI: 10.1101/2025.06.12.659230

Open publication

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