Article
p53 gene mutations in colorectal tumors from patients with familial polyposis coli.
Cancer research - 1 Jun 1991
Shirasawa S, Urabe K, Yanagawa Y, Toshitani K, Iwama T, Sasazuki T
Abstract excerpt
The p53 gene has been elucidated as a tumor suppressor gene, and inactivation of this gene caused by deletion or point mutations may play a crucial role in the development of human malignancies. In colorectal carcinomas with an allelic deletion of the p53 gene, the remaining p53 gene was mutated with considerable frequency. It is most difficult to detect point mutations or small deletions of the gene because the...
Topics
- Adenomatous Polyposis Coli
- Alleles
- Amino Acid Sequence
- Chromosome Deletion
- Chromosomes, Human, Pair 17
- Colorectal Neoplasms
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction