Article
[The significance of p53 gene mutations and expressions in human colorectal tumors].
Zhonghua zhong liu za zhi [Chinese journal of oncology] - 1 Sept 1995
Qian H, Yu B, Zhou X
Abstract excerpt
Using a polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) approach we analyzed 18 human colorectal adenocarcinomas for mutations in exons 5, 6, 7, 8 of p53 gene. At the same time, p53 gene product expression was studied immunohistochemically in these 18 cases in frozen sections. The expression of p53 protein was also immunohistochemically studied in formalin-fixed paraffin embedded...
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