Somatic mutations of the adenomatous polyposis coli gene in gastroduodenal tumors from patients with familial adenomatous polyposis.

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Article

Somatic mutations of the adenomatous polyposis coli gene in gastroduodenal tumors from patients with familial adenomatous polyposis.

Cancer research - 15 Jul 1995

Toyooka M, Konishi M, Kikuchi-Yanoshita R, Iwama T, Miyaki M

Abstract excerpt

We analyzed somatic mutations of the adenomatous polyposis coli (APC), p53, and K-ras genes in gastroduodenal polyps and normal gastroduodenal mucosa from 21 familial adenomatous polyposis patients, using PCR-single-strand conformation polymorphism and direct sequencing methods. Seventy-five poly...

Topics

Adenomatous Polyposis Coli
Adult
Base Sequence
Codon
Duodenal Neoplasms
Exons
Female
Genes, APC
Humans
Intestinal Mucosa
Intestinal Polyps
Male
Middle Aged
Molecular Sequence Data
Mutation
Stomach Neoplasms

Source

Open in PubMed

Identifiers

PMID: 7606737

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7606737-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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