Article
p53 mutations in colorectal cancer.
Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1990
Rodrigues N R, Rowan A, Smith M E, Kerr I B, Bodmer W F, Gannon J V, Lane D P
Abstract excerpt
Immunohistological staining of primary colorectal carcinomas with antibodies specific to p53 demonstrated gross overexpression of the protein in approximately 50% of the malignant tumors examined. Benign adenomas were all negative for p53 overexpression. To determine the molecular basis for this overexpression we examined p53 protein expression in 10 colorectal cancer cell lines. Six of the cell lines expressed...
Topics
- Adenocarcinoma
- Antibodies, Monoclonal
- Base Sequence
- Cell Line
- Colonic Neoplasms
- Enzyme-Linked Immunosorbent Assay
- Epitopes
- Humans
- Immunoenzyme Techniques
- Molecular Sequence Data
- Mutation