Article
K-ras and p53 mutations in hereditary non-polyposis colorectal cancers.
International journal of cancer - 20 Feb 1997
Losi L, Ponz de Leon M, Jiricny J, Di Gregorio C, Benatti P, Percesepe A, Fante R, Roncucci L, Pedroni M, Benhattar J
Abstract excerpt
Genetic instability related to defective DNA mismatch repair genes may be involved in the pathogenesis of carcinoma in Hereditary Non-Polyposis Colorectal Cancer (HNPCC). To test that the targets of genetic instability could include critical transforming genes involved in colon tumor progression,...
Topics
- Adult
- Aged
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Primers
- Female
- Genes, p53
- Genes, ras
- Humans
- Male
- Middle Aged
- Mutation
- Neoplasm Staging
- Polymorphism, Single-Stranded Conformational
- Survival Rate
- Tumor Suppressor Protein p53