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Article

K-ras and p53 mutations in hereditary non-polyposis colorectal cancers.

International journal of cancer - 20 Feb 1997

Losi L, Ponz de Leon M, Jiricny J, Di Gregorio C, Benatti P, Percesepe A, Fante R, Roncucci L, Pedroni M, Benhattar J

Abstract excerpt

Genetic instability related to defective DNA mismatch repair genes may be involved in the pathogenesis of carcinoma in Hereditary Non-Polyposis Colorectal Cancer (HNPCC). To test that the targets of genetic instability could include critical transforming genes involved in colon tumor progression, we examined 23 colorectal carcinomas in patients with HNPCC in order to detect somatic mutations in K-ras and p53...

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Identifiers

PMID: 9036876
DOI: 10.1002/(sici)1097-0215(19970220)74:1<94::aid-ijc16>3.0.co;2-i

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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