Article
Detailed analysis of genetic alterations in colorectal tumors from patients with and without familial adenomatous polyposis (FAP).
Oncogene - 1 Sept 1993
Ichii S, Takeda S, Horii A, Nakatsuru S, Miyoshi Y, Emi M, Fujiwara Y, Koyama K, Furuyama J, Utsunomiya J
Abstract excerpt
To examine early genetic events during colorectal carcinogenesis, we searched for genetic alterations in 75 adenomas from seven patients with familial polyposis coli (FAP) and in 64 sporadic colorectal tumors (63 carcinomas and one adenoma). We investigated germ-line and somatic mutations in the...
Topics
- Adenomatous Polyposis Coli
- Base Sequence
- Chromosome Deletion
- Chromosomes, Human, Pair 5
- Chromosomes, Human, Pair 8
- Colorectal Neoplasms
- Genes, APC
- Genes, p53
- Genes, ras
- Humans
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Proto-Oncogene Proteins p21(ras)