No evidence for overexpression of the p53 protein and mutations in exons 4-9 of the p53 gene in a large family with adenomatous polyposis.

doi:10.1111/j.1572-0241.1998.00414.x

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Article

No evidence for overexpression of the p53 protein and mutations in exons 4-9 of the p53 gene in a large family with adenomatous polyposis.

The American journal of gastroenterology - 1 Sept 1998

Aktas D, Ayhan A, Tunçbilek E, Ozdemir A, Uzunalimoğlu B

Abstract excerpt

OBJECTIVE: Familial adenomatous polyposis coli (FAP) is an autosomal dominant disease characterized by an early onset of numerous adenomatous polyps of the colon and a high risk of colon carcinoma. The role of the p53 gene in the multistage process of FAP is as yet poorly defined. In the present...

Topics

Adenomatous Polyposis Coli
Adult
Exons
Female
Genes, p53
Humans
Male
Mutation
Pedigree
Tumor Suppressor Protein p53

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