Article
Targeting the genes of angiotensin receptors.
Seminars in nephrology - 1 Sept 1997
Matsusaka T, Fogo A, Ichikawa I
Abstract excerpt
Gene targeting technology has produced mutant mice carrying selective null-mutation of the genes for the components of the renin-angiotensin system. Angiotensinogen null-mutant mice showed not only severe hypotension, but also several abnormal phenotypes in the kidney, including juxtaglomerular (JG) cell hypertrophy, renal arterial hypertrophy, and hypoplastic papilla. Although angiotensin type 1A (AT1A) receptor...
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