Article
Targeting the genes of angiotensin receptors.
Seminars in nephrology - 1 Sept 1997
Matsusaka T, Fogo A, Ichikawa I
Abstract excerpt
Gene targeting technology has produced mutant mice carrying selective null-mutation of the genes for the components of the renin-angiotensin system. Angiotensinogen null-mutant mice showed not only severe hypotension, but also several abnormal phenotypes in the kidney, including juxtaglomerular (...
Topics
- Angiotensin II
- Animals
- Gene Expression
- Hypertension
- Mice
- Mice, Mutant Strains
- Phenotype
- Receptors, Angiotensin
- Renal Artery