Article
Erythropoiesis and Blood Pressure Are Regulated via AT1 Receptor by Distinctive Pathways.
PloS one - 1 Jan 2015
Kato Hideki, Ishida Junji, Matsusaka Taiji, Ishimaru Tomohiro, Tanimoto Keiji, Sugiyama Fumihiro, Yagami Ken-Ichi, Nangaku Masaomi, Fukamizu Akiyoshi
Abstract excerpt
The renin-angiotensin system (RAS) plays a central role in blood pressure regulation. Although clinical and experimental studies have suggested that inhibition of RAS is associated with progression of anemia, little evidence is available to support this claim. Here we report that knockout mice that lack angiotensin II, including angiotensinogen and renin knockout mice, exhibit anemia. The anemia of...
Topics
- Anemia
- Angiotensinogen
- Animals
- Blood Pressure
- Erythropoiesis
- Erythropoietin
- Hematocrit
- Heterozygote
- Homozygote
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Phenotype