Article
Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes.
The Journal of clinical investigation - 15 Feb 1998
Tsuchida S, Matsusaka T, Chen X, Okubo S, Niimura F, Nishimura H, Fogo A, Utsunomiya H, Inagami T, Ichikawa I
Abstract excerpt
Rodents are the unique species carrying duplicated angiotensin (Ang) type 1 (AT1) receptor genes, Agtr1a and Agtr1b. After separately generating Agtr1a and Agtr1b null mutant mice by gene targeting, we produced double mutant mice homozygous for both Agtr1a and Agtr1b null mutation (Agtr1a-/-; Agt...
Topics
- Adrenal Glands
- Anesthetics
- Angiotensin II
- Angiotensinogen
- Animals
- Benzimidazoles
- Biphenyl Compounds
- Blood Pressure
- Imidazoles
- Infusions, Intravenous
- Kidney
- Losartan
- Mice
- Mice, Knockout