Article
Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts.
Cardiovascular research - 1 Jun 2010
van Esch Joep H M, Gembardt Florian, Sterner-Kock Anja, Heringer-Walther Silvia, Le Thu H, Lassner Dirk, Stijnen Theo, Coffman Thomas M, Schultheiss Heinz-Peter, Danser A H Jan, Walther Thomas
Abstract excerpt
AIMS: Our aim was to determine the contribution of the three angiotensin (Ang) II receptor subtypes (AT(1a), AT(1b), AT(2)) to coronary responsiveness, cardiac histopathology, and tissue Ang II levels using mice deficient for one, two, or all three Ang II receptors. METHODS AND RESULTS: Hearts of knockout mice and their wild-type controls were collected for histochemistry or perfused according to Langendorff, and...
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