A comparison between p53 accumulation determined by immunohistochemistry and<i>TP53</i>mutations as prognostic variables in tumours from breast cancer patients

Abstract excerpt

BACKGROUND: p53 accumulation and TP53 mutations are known prognostic markers for breast cancer. To clarify their interrelationship and the importance of different TP53 mutation types, these markers were investigated in tumours from 630 patients with breast cancer. MATERIALS AND METHODS: Tumour sections were stained for p53 and scored based on staining intensity and percentages of invasive tumour cells with...

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