Article

P53 immunohistochemistry is an ideal surrogate marker for TP53 mutation and a predictor of early metastasis in breast cancer: Real-world analysis

2024-04-25

Abstract excerpt

<title>Abstract</title> <p>Purpose:<italic> TP53</italic> mutation in breast cancer (BC) is associated with chemoresistance, endocrine resistance, and late recurrence, resulting in poor prognosis. Nuclear accumulation of p53 in immunohistochemistry (IHC) is a surrogate marker of <italic>TP53</italic> mutation. We analyzed the frequency, type, and distribution of <italic>TP53</italic> mutations in BCs and assessed...

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Literature Corpus work: dda5aafd-1396-52a5-a743-721a51da71bc
DOI: 10.21203/rs.3.rs-4281204/v1

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