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Article

Distinct tumor protein p53 mutants in breast cancer subgroups.

International journal of cancer - 1 Mar 2013

Dumay Anne, Feugeas Jean-Paul, Wittmer Evelyne, Lehmann-Che Jacqueline, Bertheau Philippe, Espié Marc, Plassa Louis-François, Cottu Paul, Marty Michel, André Fabrice, Sotiriou Christos, Pusztai Lajos, de Thé Hugues

Abstract excerpt

Tumor protein p53 (TP53) is mutated in approximately 30% of breast cancers, but this frequency fluctuates widely between subclasses. We investigated the p53 mutation status in 572 breast tumors, classified into luminal, basal and molecular apocrine subgroups. As expected, the lowest mutation frequency was observed in luminal (26%), and the highest in basal (88%) tumors. Luminal tumors showed significantly higher...

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Identifiers

PMID: 22886769
DOI: 10.1002/ijc.27767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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