Article
Mutant p53 accumulation in human breast cancer is not an intrinsic property or dependent on structural or functional disruption but is regulated by exogenous stress and receptor status.
The Journal of pathology - 1 Jul 2014
Bouchalova Pavla, Nenutil Rudolf, Muller Petr, Hrstka Roman, Appleyard M Virginia, Murray Karen, Jordan Lee B, Purdie Colin A, Quinlan Philip, Thompson Alastair M, Vojtesek Borivoj, Coates Philip J
Abstract excerpt
Many human cancers contain missense TP53 mutations that result in p53 protein accumulation. Although generally considered as a single class of mutations that abrogate wild-type function, individual TP53 mutations may have specific properties and prognostic effects. Tumours that contain missense TP53 mutations show variable p53 stabilization patterns, which may reflect the specific mutation and/or aspects of...
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