Article
Influence of mutation type on prognostic and predictive values of TP53 status in primary breast cancer patients.
Oncology reports - 1 Oct 2014
Dobes Petr, Podhorec Jan, Coufal Oldrich, Jureckova Andrea, Petrakova Katarina, Vojtesek Borivoj, Hrstka Roman
Abstract excerpt
High rates of mutation in the TP53 tumor suppressor gene have been found in many human cancers, including breast tumors, making p53 one of the most studied proteins in oncology. However, the prognostic and predictive value of alterations in this gene remains ambiguous. To analyze the clinical value of somatic TP53 mutations, we collected clinical and molecular data on 210 women with primary breast cancer. We...
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