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Correlating p53 immunostaining patterns with somatic TP53 mutation and functional properties of mutant p53 in triple‐negative breast cancer

31 Mar 2025

Abstract excerpt

AIMS: Immunohistochemical (IHC) staining of p53 is a potential marker for TP53 mutations in various cancers. However, criteria for predicting TP53 mutations in triple-negative breast cancer (TNBC) using p53 IHC staining are not yet established. We aim to correlate p53 IHC expression patterns with TP53 mutation status in TNBC. METHODS AND RESULTS: A total of 113 TNBC cases were analysed for p53 IHC staining...

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PMID: 40162573
DOI: 10.1111/his.15453

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