Platelet-derived growth factor receptor alpha-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation.

doi:10.1073/pnas.88.1.6

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Article

Platelet-derived growth factor receptor alpha-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1991

Stephenson D A, Mercola M, Anderson E, Wang C Y, Stiles C D, Bowen-Pope D F, Chapman V M

Abstract excerpt

Platelet-derived growth factor receptors are composed of two subunits (alpha and beta) that associate with one another to form three functionally active dimeric receptor species. The two subunits are encoded by separate loci in humans and other species. In this study, we used conventional intersp...

Topics

Animals
Blotting, Southern
Chromosome Deletion
Crosses, Genetic
DNA
Female
Genetic Carrier Screening
Genetic Linkage
Macromolecular Substances
Male
Mice
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Mutant Strains

Mutation

Nucleic Acid Hybridization

Platelet-Derived Growth Factor

Receptors, Cell Surface

Receptors, Platelet-Derived Growth Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 1846043
DOI: 10.1073/pnas.88.1.6
PMCID: PMC50736

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1846043-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Platelet-derived growth factor receptor alpha-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation.PMID 1846043Read ↗

Mouse platelet-derived growth factor receptor alpha gene is deleted in W19H and patch mutations on chromosome 5.Semantic proximity Read ↗

Analysis of the Kit and Pdgfra genes in the patch-extended (Phe) mutation.Semantic proximity Read ↗

Developmental expression of the alpha receptor for platelet-derived growth factor, which is deleted in the embryonic lethal Patch mutation.Semantic proximity Read ↗

Structural analysis of chromosomal rearrangements associated with the developmental mutations Ph, W19H, and Rw on mouse chromosome 5.Semantic proximity Read ↗

A PDGF receptor mutation in the mouse (Patch) perturbs the development of a non-neuronal subset of neural crest-derived cells.Semantic proximity Read ↗

Mouse rump-white mutation associated with an inversion of chromosome 5.Semantic proximity Read ↗

The Wsh and Ph mutations affect the c-kit expression profile: c-kit misexpression in embryogenesis impairs melanogenesis in Wsh and Ph mutant mice.Semantic proximity Read ↗

Regulation and role of PDGF receptor alpha-subunit expression during embryogenesis.Semantic proximity Read ↗

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The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions.Semantic proximity Read ↗

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The Wsh, W57, and Ph Kit Expression Mutations Define Tissue-Specific Control Elements Located Between −23 and −154 kb Upstream of KitSemantic proximity Read ↗

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