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Article

Platelet-derived growth factor receptor alpha-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1991

Stephenson D A, Mercola M, Anderson E, Wang C Y, Stiles C D, Bowen-Pope D F, Chapman V M

Abstract excerpt

Platelet-derived growth factor receptors are composed of two subunits (alpha and beta) that associate with one another to form three functionally active dimeric receptor species. The two subunits are encoded by separate loci in humans and other species. In this study, we used conventional interspecific backcross mapping and an analysis of a deletional mutation to establish close linkage between the alpha-subunit...

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Source

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Identifiers

PMID: 1846043
DOI: 10.1073/pnas.88.1.6
PMCID: PMC50736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Platelet-derived growth factor receptor alpha-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation.PMID 1846043Read ↗

Mouse platelet-derived growth factor receptor alpha gene is deleted in W19H and patch mutations on chromosome 5.Semantic proximity Read ↗

Analysis of the Kit and Pdgfra genes in the patch-extended (Phe) mutation.Semantic proximity Read ↗

Developmental expression of the alpha receptor for platelet-derived growth factor, which is deleted in the embryonic lethal Patch mutation.Semantic proximity Read ↗

Structural analysis of chromosomal rearrangements associated with the developmental mutations Ph, W19H, and Rw on mouse chromosome 5.Semantic proximity Read ↗

A PDGF receptor mutation in the mouse (Patch) perturbs the development of a non-neuronal subset of neural crest-derived cells.Semantic proximity Read ↗

Mouse rump-white mutation associated with an inversion of chromosome 5.Semantic proximity Read ↗

The Wsh and Ph mutations affect the c-kit expression profile: c-kit misexpression in embryogenesis impairs melanogenesis in Wsh and Ph mutant mice.Semantic proximity Read ↗

Regulation and role of PDGF receptor alpha-subunit expression during embryogenesis.Semantic proximity Read ↗

The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites.Semantic proximity Read ↗

The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions.Semantic proximity Read ↗

Insight into the physiological functions of PDGF through genetic studies in mice.Semantic proximity Read ↗

The Wsh, W57, and Ph Kit Expression Mutations Define Tissue-Specific Control Elements Located Between −23 and −154 kb Upstream of KitSemantic proximity Read ↗

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