Analysis of the Kit and Pdgfra genes in the patch-extended (Phe) mutation.

doi:10.1017/s0016672398003425

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Article

Analysis of the Kit and Pdgfra genes in the patch-extended (Phe) mutation.

Genetical research - 1 Dec 1998

Stephenson D A, Novak E K, Chapman V M

Abstract excerpt

The patch (Ph) locus allele, patch-extended (Phe), has significantly less pigmentation than the original mutation and homozygotes have been known to survive to term. Analysing intersubspecific F1 hybrids, we were able to demonstrate that Phe is a deletional mutation encompassing the platelet-derived growth factor receptor alpha subunit (Pdgfra). The deletion does not appear to extend into the coding sequence of...

Topics

Animals
Brain
Heterozygote
Mice
Mice, Inbred Strains
Mutation
Phenotype
Phosphorylation
Pigmentation
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Proto-Oncogene Proteins c-kit
RNA, Messenger
Receptor, Platelet-Derived Growth Factor alpha
Receptors, Platelet-Derived Growth Factor
Sequence Deletion
Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 10036976
DOI: 10.1017/s0016672398003425

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