Article
Regulation and role of PDGF receptor alpha-subunit expression during embryogenesis.
Development (Cambridge, England) - 1 May 1992
Schatteman G C, Morrison-Graham K, van Koppen A, Weston J A, Bowen-Pope D F
Abstract excerpt
The platelet-derived growth factor receptor alpha-subunit (PDGFR alpha) is the form of the PDGF receptor that is required for binding of PDGF A-chain. Expression of PDGFR alpha within the early embryo is first detected as the mesoderm forms, and remains characteristic of many mesodermal derivatives during later development. By 9.5 days of development, embryos homozygous for the Patch mutation (a deletion of the...
Topics
- Animals
- Blotting, Northern
- Central Nervous System
- Gene Expression
- Gene Expression Regulation
- Mesoderm
- Mice
- Mice, Inbred Strains
- Microscopy, Fluorescence
- Molecular Probe Techniques
- Mutation