Article
Mouse platelet-derived growth factor receptor alpha gene is deleted in W19H and patch mutations on chromosome 5.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1991
Smith E A, Seldin M F, Martinez L, Watson M L, Choudhury G G, Lalley P A, Pierce J, Aaronson S, Barker J, Naylor S L
Abstract excerpt
The mouse W19H mutation is an x-ray-induced deletion of more than 2 centimorgans on chromosome 5 encompassing the white spotting mutation W (encoded by the Kit protooncogene), patch (Ph), and recessive lethal (l) loci. The platelet-derived growth factor receptor alpha gene (PDGFRA) like Kit encodes a transmembrane receptor tyrosine kinase. By using mouse-Chinese hamster somatic cell hybrids and haplotype analysis...
Topics
- Animals
- Blotting, Southern
- Chromosome Deletion
- Chromosome Mapping
- Cricetinae
- Cricetulus
- DNA
- Female
- Genetic Linkage
- Hybrid Cells
- Male