Article
Structural analysis of chromosomal rearrangements associated with the developmental mutations Ph, W19H, and Rw on mouse chromosome 5.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 1994
Nagle D L, Martin-DeLeon P, Hough R B, Bućan M
Abstract excerpt
We are studying the chromosomal structure of three developmental mutations, dominant spotting (W), patch (Ph), and rump white (Rw) on mouse chromosome 5. These mutations are clustered in a region containing three genes encoding tyrosine kinase receptors (Kit, Pdgfra, and Flk1). Using probes for these genes and for a closely linked locus, D5Mn125, we established a high-resolution physical map covering...
Topics
- Animals
- Chromosome Aberrations
- Electrophoresis, Gel, Pulsed-Field
- Gene Deletion
- Gene Rearrangement
- Genes, Lethal
- Genetic Complementation Test
- Genetic Linkage
- Humans
- Mice