Article
The Wsh and Ph mutations affect the c-kit expression profile: c-kit misexpression in embryogenesis impairs melanogenesis in Wsh and Ph mutant mice.
Proceedings of the National Academy of Sciences of the United States of America - 25 Apr 1995
Duttlinger R, Manova K, Berrozpe G, Chu T Y, DeLeon V, Timokhina I, Chaganti R S, Zelenetz A D, Bachvarova R F, Besmer P
Abstract excerpt
The receptor tyrosine kinases (RTKs) c-kit and platelet-derived growth factor receptor alpha chain (PDG-FRa) are encoded at the white spotting (W) and patch (Ph) loci on mouse chromosome 5. While W mutations affect melanogenesis, gametogenesis, and hematopoiesis, the Ph mutation affects melanogenesis and causes early lethality in homozygotes. W-sash (Wsh) is an expression mutation and blocks c-kit expression in...
Topics
- Animals
- Base Sequence
- Chromosome Mapping
- DNA Primers
- Embryo, Mammalian
- Gene Expression
- Immunohistochemistry
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data