Article
The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions.
Molecular cell - 1 Feb 2001
Klinghoffer R A, Mueting-Nelsen P F, Faerman A, Shani M, Soriano P
Abstract excerpt
Gene targeting studies have indicated that the two receptors for PDGF, alpha and beta, direct unique functions during development. Distinct ligand affinities, patterns of gene expression, and/or mechanisms of signal relay may account for functional specificity of the two PDGF receptor isoforms. To distinguish between these factors, we have created two complementary lines of knockin mice in which the intracellular...
Topics
- Animals
- Cells, Cultured
- Gene Deletion
- Gene Targeting
- Genetic Complementation Test
- Genotype
- Glomerulonephritis
- Heart Defects, Congenital
- Histocytochemistry
- Kidney
- Mice
- Mice, Transgenic
- Mitogen-Activated Protein Kinases
- Phosphorylation