Article
A PDGF receptor mutation in the mouse (Patch) perturbs the development of a non-neuronal subset of neural crest-derived cells.
Development (Cambridge, England) - 1 May 1992
Morrison-Graham K, Schatteman G C, Bork T, Bowen-Pope D F, Weston J A
Abstract excerpt
The Patch (Ph) mutation in mice is a deletion of the gene encoding the platelet-derived growth factor receptor alpha subunit (PDGFR alpha). Patch is a recessive lethal recognized in heterozygotes by its effect on the pattern of neural crest-derived pigment cells, and in homozygous mutant embryos...
Topics
- Animals
- Bone and Bones
- Cornea
- Embryonic and Fetal Development
- Gene Expression
- Gene Expression Regulation
- Head
- Heart
- Mice
- Mice, Inbred Strains
- Microscopy, Electron
- Microscopy, Fluorescence
- Mutation
- Neural Crest
- Odontogenesis
- Thymus Gland