Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insight into the physiological functions of PDGF through genetic studies in mice.

Cytokine & growth factor reviews - 1 Aug 2004

Betsholtz Christer

Abstract excerpt

Genetic analyses in mice have contributed significantly to the understanding of the physiological functions of platelet-derived growth factors (PDGFs) and their receptors. Phenotypic analyses of gene knockouts of PDGF-A, PDGF-B, PDGF alpha-receptors (PDGFRalpha) and beta-receptors (PDGFRbeta) have shown that these ligands and receptors play major roles during embryonic development. Conditional and subtle...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Techniques
Share to Models, Anatomic
Share to Oligodendroglia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Platelet-Derived Growth Factor

Share to Proto-Oncogene Proteins c-sis

Share to Receptor, Platelet-Derived Growth Factor alpha

Share to Receptor, Platelet-Derived Growth Factor beta

Share to Retina

Source

Identifiers

PMID: 15207813
DOI: 10.1016/j.cytogfr.2004.03.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insight into the physiological functions of PDGF through genetic studies in mice.PMID 15207813Read ↗

Role of platelet-derived growth factors in physiology and medicine.Semantic proximity Read ↗

The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions.Semantic proximity Read ↗

PDGF signaling in cells and mice.Semantic proximity Read ↗

Platelet-derived Growth Factor Signaling and Human CancerSemantic proximity Read ↗

Roles of PDGF/PDGFR signaling in various organsSemantic proximity Read ↗

Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis.Semantic proximity Read ↗

PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα.Semantic proximity Read ↗

PDGF receptor signaling networks in normal and cancer cellsSemantic proximity Read ↗

An activating mutation in the PDGF receptor-beta causes abnormal morphology in the mouse placenta.Semantic proximity Read ↗

Deletion of the PDGFR-beta gene affects key fibroblast functions important for wound healing.Semantic proximity Read ↗

Evidence for distinct signaling properties and biological responses induced by the PDGF receptor alpha and beta subtypes.Semantic proximity Read ↗

An allelic series at the PDGFalphaR locus indicates unequal contributions of distinct signaling pathways during development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.