Article
Evidence that the gene encoding insulin degrading enzyme influences human lifespan.
Human molecular genetics - 1 Aug 2008
Hong Mun-Gwan, Reynolds Chandra, Gatz Margaret, Johansson Boo, Palmer Jennifer C, Gu Harvest F, Blennow Kaj, Kehoe Patrick G, de Faire Ulf, Pedersen Nancy L, Prince Jonathan A
Abstract excerpt
Studies in model organisms have demonstrated that components of insulin and insulin-like signaling pathways are involved in the regulation of lifespan but the relevance of those findings to humans has remained obscure. Here we provide evidence suggesting that variants of the gene encoding insulin-degrading enzyme (IDE) may be influencing human lifespan. We have employed a variety of models and diverse samples...
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