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Article

Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.

Diabetes - 1 May 2003

Groves Christopher J, Wiltshire Steven, Smedley Damian, Owen Katherine R, Frayling Timothy M, Walker Mark, Hitman Graham A, Levy Jonathan C, O'Rahilly Stephen, Menzel Stephan, Hattersley Andrew T, McCarthy Mark I

Abstract excerpt

The gene for insulin-degrading enzyme (IDE) represents a strong positional and biological candidate for type 2 diabetes susceptibility. IDE maps to chromosome 10q23.3, a region linked to diabetes in several populations; the rat homolog has been directly implicated in diabetes susceptibility; and known functions of IDE support an important role in glucose homeostasis. We sought evidence for association between IDE...

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PMID: 12716770
DOI: 10.2337/diabetes.52.5.1300

Genes

IDE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.PMID 12716770Read ↗

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