Article

Lifespan and fecundity impacts of reduced insulin signalling can be directed by mito-nuclear epistasis in <i>Drosophila</i>

2025-09-06

Abstract excerpt

The changing demography of human populations has motivated a search for interventions that promote healthy ageing, and especially for evolutionarily-conserved mechanisms that can be studied in lab systems to generate hypotheses about function in humans. Reduced Insulin/IGF signalling (IIS) is leading example, which can extend healthy lifespan in a range of animals; but whether benefits and costs of reduced IIS var...

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Literature Corpus work: a211e37d-3482-5005-972d-17b001b33de8
DOI: 10.1101/2025.09.04.674084

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